Espacio InfoSHUa
Espacio InfoSHUa
Espacio de información del Síndrome Hemolítico Urémico atípico (SHUa)
Información científica
Actualízate en SHUa con la voz de expertos.
CONTACTO: Para requerimientos informativos adicionales o más específicos contactar con la siguiente dirección que Alexion pone a su disposición
medinfo.emea@alexion.com
Información regulatoria de acceso al tratamiento
- Ficha Técnica y Prospecto de Soliris en la web de la Agencia Española del Medicamento y Productos Sanitarios (AEMPS):
https://www.aemps.gob.es/cima/publico/lista.html - Información para los profesionales sanitarios sobre Soliris en el tratamiento del SHUa:
https://cima.aemps.es/cima/DocsPub/15/813 - Información para los pacientes y sus cuidadores sobre Soliris en el tratamiento del SHUa:
https://cima.aemps.es/cima/DocsPub/16/817 - Informe Público Europeu de Evaluación (EPAR) de Soliris:
http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000791/human_med_001055.jsp&mid=WC0b01ac058001d124 - Informe de evaluación y recomendaciones del NICE de eculizumab en el tratamiento del SHUa:
https://www.nice.org.uk/guidance/hst1/resources/eculizumab-for-treating-atypical-haemolytic-uraemic-syndrome-pdf-1394895848389
Listado de publicaciones recomendadas
- Campistol JM, et al. Actualización en síndrome hemolítico urémico atípico: diagnóstico y tratamiento. Documento de consenso. Nefrologia. 2015.
Este documento de consenso proporciona información de un grupo de expertos español, sobre la clasificación etiológica de las MAT, la fisiopatología del SHUa, su diagnóstico diferencial y recomendaciones sobre su manejo terapéutico en pacientes adultos y pediátricos con SHUa.
En pacientes pediátricos el diagnóstico se basa fundamentalmente en la clínica y en consecuencia, ante la sospecha fundada de SHUa en un paciente pediátrico se recomienda iniciar precozmente la administración de eculizumab como tratamiento de elección en primera línea. Además, se recomienda que sean tranferidos a centros especializados de nefrología pediátrica, con personal experimentado y unidad de cuidados intensivos pediátricos, para garantizar su tratamiento adecuado. - Goodship, Timothy HJ, et al. "Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes”(KDIGO) Controversies Conference." Kidney international 91.3 (2017): 539-551.
Aquí se reportan los resultados de una conferencia de controversias de un panel global de expertos donde se discutió acerca del manejo de dos enfermedades en las que el complemento juega un papel importante, el SHUa y la glomerulopatía C3.
Las áreas de discusión incluyeron la patología renal, fenotipo clínico y evaluación, factores genéticos o adquiridos, y estrategias de tratamiento.
En aras de ayudar a los clínicos en el tratamiento de sus pacientes, se hacen recomendaciones sobre las mejores estrategias de tratamiento discutiendo acerca de su duración, y proporcionando evidencias basadas en las actuales opciones terapéuticas. - Diseases of complement dysregulation-an overview.
Wong EKS, Kavanagh D.
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